Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques

Sperm chromatin structure assay parameters as predictors of failed pregnancy following assisted reproductive techniques.

The predictive value of sperm chromatin integrity for pregnancy outcome following in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) was studied in 24 men attending a university-based assisted reproductive techniques laboratory using the flow cytometric sperm chromatin structure assay (SCSA). The SCSA is a measure of the susceptibility of sperm DNA to low pH-induced denatu...

Heterotopic Pregnancy after Assisted Reproductive Techniques

Heterotopic pregnancy (HP) is the simultaneous occurrence of intra- and extrauterine pregnancies. It is a rare event in spontaneous pregnancies with an incidence of less than 1:15000 however the frequency has increased to 1% in accordance with the widespread use of assisted reproductive techniques (ART). The pre-operative diagnosis of this condition is generally difficult and it would be life t...

the role of sperm chromatin anomalies on the outcome of assisted reproductive techniques

sperm dna is known to contribute one half of the genomic material to the offspring. the integrity of sperm dna is important in fertilization, embryonic and fetal development, and postnatal child well being. the nature has created multiple barriers that allow only the fittest sperm to reach and fertilize an oocyte. however, assisted reproductive techniques (art), like ivf and icsi, may allow spe...

Cervical Ectopic Pregnancy following Assisted Reproductive Technology: A Case Report

Environmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA).

Studies over the past two decades have clearly shown that reproductive toxicants cause sperm DNA fragmentation. This DNA fragmentation can usually be detected prior to observing alterations of metaphase chromosomes in embryos. Thus, Sperm Chromatin Structure Assay (SCSA)-detected DNA damage is viewed as the molecular precursor to later gross chromosome damage observed under the light microscope...